A mechanism that controls the genomic structure during early differentiation into neuroectoderm

A group of scientists have discovered that a one of the components of the polycomb-type of transcriptional repressor complex (PRC), Phc1 (Rae28), regulates the chromatin state of cells and plays a critical role in the process of undifferentiated cells turning into neural progenitor cells (fig. 1). The research from the Nara Institute of Science and Technology (NAIST), the National Cardiovascular Center, and Japanese Red Cross Kinki Block Blood Center has been published in the October 20, 2023, issue of the journal iScience.