AI model simulates 500 million years of evolution to generate a new fluorescent protein

A team of AI researchers, biologists and evolutionary specialists at EvolutionaryScale and the Arc Institute, both in the U.S., has designed and built an AI model capable of generating the code to synthesize novel proteins. In their paper published in the journal Science, the group describes the factors that went into developing their new AI model, which they call ESM3, and how they used it to synthesize a previously unknown bright, fluorescent protein.