Computer simulations reveal how cells break down the endoplasmic reticulum

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed—for instance in case of a nutrient deficiency. As part of this process, bulges or protrusions form in the membrane, which then pinch off and are recycled by the cell.