Copper radical mimics enzyme for highly efficient C-H oxidation

Optically pure alcohols are prevalent motifs in natural products and pharmaceuticals, driving the development of effective methods for their synthesis. Since the first reports of the Kharasch-Sosnovsky reaction in 1958, the copper-catalyzed radical-mediated sp3 C-H oxidation has emerged as an important method for the selective oxidation of allylic, propargylic, and other sp3 C-H bonds.