Drum mills achieve kilogram-scale ibuprofen synthesis with green technique

For the first time, researchers used drum mills to make kilograms of ibuprofen-nicotinamide, a formulation that improves therapeutic efficacy and stability. This is part of European project IMPACTIVE, focused on studying mechanochemical methods to make pharma manufacturing more sustainable, reducing both carbon emissions and chemical waste. Now, the team have produced over 3 kilograms of racemic ibuprofen-nicotinamide co-crystals, pioneering the use of this green technique for large-scale synthesis.