Going slow is better for fast cycling: Study reveals unique replication fork behavior in pluripotent stem cells

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic replication stress. However, a recent report published in EMBO Reports by Kurashima and team challenge this assumption by providing a detailed molecular investigation of replication dynamics in these cells.