Harnessing compact RNA-guided endonucleases for enhanced genome editing

The review paper "CRISPR Beyond: Harnessing Compact RNA-Guided Endonucleases for Enhanced Genome Editing," authored by Feizuo Wang from National University of Singapore, presents a comprehensive examination of the advancements in CRISPR-Cas technologies. Their collective expertise focuses on addressing a critical bottleneck in the field: the significant size of traditional CRISPR-Cas systems, which poses challenges for efficient delivery into target cells and organisms. This barrier has limited the application of CRISPR technologies in therapeutic contexts, prompting the need for innovative solutions.