Researchers elucidate how IGF2's secretory pathway mediates muscle stem cell differentiation

A research team led by the Hong Kong University of Science and Technology (HKUST) recently revealed how TMED10, a type of transmembrane protein, regulates muscle stem cell differentiation through mediating the secretion of insulin-like growth factor 2 (IGF2). This provides potential therapeutic strategies to downregulate IGF2 signaling by inhibiting its secretion.