Throughout the history of RNA research, one can immediately notice a significant breakthrough during 2007 and 2008, in which several groups independently reported the discovery of intact noncoding RNA (ncRNA) sequences in extracellular space. Later on, the discovery of these extracellular ncRNAs led to a scope switch of RNA study, from their regulatory roles within the cells to signaling properties in cell-to-cell communications.
Source:
phys.org