Researchers reveal molecular mechanism of crown ether microsolvation effect on gas-phase native-like protein structure

A research group led by Prof. Wang Fangjun from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS), in collaboration with Prof. Shun Feng from Southwest Jiaotong University, has revealed the molecular mechanism of the crown ether microsolvation effect on the gas-phase native-like protein structure by integrating native mass spectrometry (nMS) with 193 nm ultraviolet photodissociation (UVPD).