Spain has confirmed its second death from the Monkeypox virus as cases continue to climb worldwide.
The country's Ministry of Health confirmed the fatality on Saturday, as its caseload grew to 4,298.
Out of these, 120 have required hospitalisation, reported El Mundo, representing 3.2 per cent of cases.
It comes after a 41-year-old man from Alicante, in the Valencia region, became the first death in Europe.
Last week the World Health Organisation declared monkeypox a global health emergency, meaning it now views the current outbreak as enough of a significant threat that a coordinated international response is needed.
Spain has the most cases in Europe and is beaten only by the US at the global level.
Monkeypox has affected more than 16,000 people across 75 countries, according to a tally by the US Centers for Disease Control and Prevention (CDC)
WHO Director-General Tedros Adhanom Ghebreyesus made the decision to issue the declaration despite a lack of consensus among experts serving on the U.N. health agency's emergency committee.
It was the first time the chief of the U.N. health agency has taken such an action.
'We have an outbreak that has spread around the world rapidly through new modes of transmission about which we understand too little and which meets the criteria in the international health regulations,' Tedros said.
'I know this has not been an easy or straightforward process and that there are divergent views among the members of the committee,' he added.
The WHO announcement came after the virus spread to more than 75 countries. Director General Dr Tedros said at the time the risk of people catching the virus in Europe was 'high'.
The WHO previously declared emergencies for public health crises such as the Covid-19 pandemic, the 2014 West African Ebola outbreak, the Zika virus in Latin America in 2016 and the ongoing effort to eradicate polio.