Structural insight into process of gene regulation

In the cell nucleus, numerous proteins bind to the DNA molecule in order to regulate the activity of certain genes. One of these is the TATA-box binding protein (TBP), which binds to a specific DNA sequence and constitutes an initial signal for the reading of DNA. Incorrectly bound TBP is removed from the DNA by a special enzyme called Mot1 and "recycled." This enzyme belongs to a large family of molecular machines, the so-called Swi2/Snf2 remodelers, which use the energy from ATP to break protein-DNA bonds.