Study describes the structural and functional effects of several mutations on the androgen receptor

The androgen receptor is a key transcriptional factor for the proper sex development—especially in males—and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment.