Study finds a thyroxine derivative enhances brain drug delivery

A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule. The transporter protein OATP1C1, which is found in the brain, can be utilized in the delivery of such prodrugs. The results were published in Journal of Medicinal Chemistry.