Understanding how cohesin makes DNA loops in the human genome and its role in Cornelia de Lange syndrome

Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology in recent decades. A study now published by researcher Ana Losada's group at The Spanish National Cancer Research Centre (CNIO) will serve to deepen our understanding of the disease known as Cornelia de Lange syndrome.