Vinigrol targets protein disulfide isomerase to block inflammatory response, shows study

Researchers led by Prof. Wang Lei from the Institute of Biophysics of the Chinese Academy of Science (CAS) and their collaborators have identified the direct target of vinigrol as protein disulfide isomerase (PDI) on the cell membrane. Vinigrol activates ADAM17 protease by inhibiting PDI, and then leads to the shedding of immune receptors TNFR1, thereby antagonizing the TNF-α signaling.